Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet
نویسندگان
چکیده
منابع مشابه
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet
BACKGROUND Mammalian sirtuins are homologs to the yeast silent information regulator 2 (Sir2), which is an NAD-dependent deacetylase. Sirtuins are comprised of 7 proteins, and each has different target proteins. Sirtuin 1 (SIRT1) plays important roles in maintaining metabolic functions and immune responses, and SIRT3 protects cells from oxidative stress-induced cell death. Both SIRT1 and SIRT3 ...
متن کاملSirtuin 1 and sirtuin 3: physiological modulators of metabolism.
The sirtuins are a family of highly conserved NAD(+)-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are mammalian sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), which are localized to the nucleus and mitochondria, respectively. Both are activated by high NAD(+) leve...
متن کاملChanges in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis.
OBJECTIVE Sirtuins (SIRTs) play a prominent role in metabolism, apoptosis, aging, inflammation, and epigenetics. Inflammation, apoptosis, and epigenetics are pathogenic issues in rheumatoid arthritis (RA). This study aimed to evaluate SIRT2 and SIRT3 mRNA expressions in patients with RA. MATERIAL AND METHODS Fifty-four patients with RA and 26 healthy controls were enrolled. Disease activity w...
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BACKGROUND Recent studies revealed that sirtuin 1 (SIRT1) has a relation to the mechanism of transforming growth factor-beta (TGF-beta) mediated apoptosis in glomerular mesangial cells and plays an important role in blood pressure regulation. It has been suggested that SIRT1 contributes to the renoprotective effect of angiotensin receptor blocker (ARB), but this has not yet become clearly recog...
متن کاملProtective Effects of Restricted Diet and Antioxidants on Testis Tissue in Rats Fed with High-Fat Diet
Background: A high-fat diet (HFD) and fat accumulation promote the oxidative stress formation, which in turn has hazardous effects on reproductive system and fertility. Therefore, the present study examines the potential positive effects of a restricted high-fat diet (RHFD) and antioxidants consumption on sperm parameters in rats. Methods: 48 male albino wistar rats divided to four groups (n=12...
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ژورنال
عنوان ژورنال: BMC Veterinary Research
سال: 2013
ISSN: 1746-6148
DOI: 10.1186/1746-6148-9-187